This medicine is an anticonvulsant that works in the brain tissue to stop seizures
Furthermore, VPA has gained substantial recognition for its effectiveness in preventing migraine headaches since the FDA
Long Half-Life At usual therapeutic levels, valproic acid is known to be approximately 90% protein bound, and demonstrates a rather small volume of distribution (0
The half-life in neonates ranges from 10-67 hours while the half-life in pediatric patients under 2 months of age ranges from 7-13 hours
Valproic acid, commonly used in neuropsychiatry, has an elimination half-life of 4 16 hours in different populations (children vs adults, enzyme-induced vs uninduced)
Valproic acid is an agent that is chemically related to free fatty acids and is used in the treatment of generalized, partial, and absence (petit mal) seizures
The total plasma clearance of valproic acid is in the range of 5 to 10ml/min
In children the half-life of valproic acid alone is 10 to 11 hours; when other
Valproic acid is highly protein bound to albumin with typical values of 90–95%
Small amounts also are excreted in feces and in expired air
Half-life: 7-13 hr (>2 months); 9-16 hr (adults) Dialyzable: Yes
phenobarbital, primidone, rifampin, lopinavir/ritonavir, atazanavir, ritonavir, and valproic acid
, on a daily basis), but be aware that levels will continue to rise for a few days following dose escalation! Valproic acid, commonly used in neuropsychiatry for treatment of epilepsy, bipolar disorder and prophylaxis of migraine headaches, has a short elimination half-life of 12 16 hours in adults taking acid in a 1:1 molar relationship and formed during the partial neutralization of valproic acid with 0
05 L/h/kg)
8) has a molecular weight of 144 and occurs as a colorless liquid with a characteristic odor
Intravenous valproic acid lends itself well to a continuous infusion as it exhibits a relatively short half-life
Seek medical treatment if you have a serious drug reaction that can affect
Mean terminal half-life is about 14 hours, steady state conditions usually being achieved within 3 – 4 days
In children the half-life of valproic acid alone is 10 to 11 hours; when other medications are added, half-life may be reduced to 8 to 9 hours
Effects on Isoenzymes
Valproic acid is extensively metabolised by microsomal glucuronide conjugation, mitochondrial beta-oxidation and cytochrome P450-dependent omega-, (omega-1)- and (omega-2)-oxidation
14,46,65 Coadministration of lamotrigine with valproic acid/divalproex sodium/valproate sodium leads to decreased elimination of lamotrigine, increased half-life from 30 to 60 Valproic acid (VPA) is commonly used medication to treat seizure disorder and as prophylaxis for bipolar disorder